CALL FOR PAPERS Neurohypophyseal Hormones: From Genomics and Physiology to Disease Sodium-level-sensitive sodium channel Nax is expressed in glial laminate processes in the sensory circumventricular organs
نویسندگان
چکیده
Eiji Watanabe, Takeshi Y. Hiyama, Hidetada Shimizu, Ryuji Kodama, Noriko Hayashi, Seiji Miyata, Yuchio Yanagawa, Kunihiko Obata, and Masaharu Noda Laboratory of Neurophysiology, Division of Molecular Neurobiology, and Laboratory of Morphodiversity, National Institute for Basic Biology, Okazaki, Aichi; School of Life Science, The Graduate University for Advanced Studies, Okazaki, Aichi; Department of Applied Biology, Kyoto Institute for Technology, Matsugasaki, Sakyo, Kyoto; Department of Genetic and Behavioral Neuroscience, Graduate School of Medicine, Gunma University, Maebashi, Gunma; and The Institute of Physical and Chemical Research, Brain Science Institute, Wako, Saitama, Japan
منابع مشابه
Sodium-level-sensitive sodium channel Na(x) is expressed in glial laminate processes in the sensory circumventricular organs.
Na(x) is an atypical sodium channel that is assumed to be a descendant of the voltage-gated sodium channel family. Our recent studies on the Na(x)-gene-targeting mouse revealed that Na(x) channel is localized to the circumventricular organs (CVOs), the central loci for the salt and water homeostasis in mammals, where the Na(x) channel serves as a sodium-level sensor of the body fluid. To unders...
متن کاملChannel Properties of Nax Expressed in Neurons
Nax is a sodium-concentration ([Na+])-sensitive Na channel with a gating threshold of ~150 mM for extracellular [Na+] ([Na+]o) in vitro. We previously reported that Nax was preferentially expressed in the glial cells of sensory circumventricular organs including the subfornical organ, and was involved in [Na+] sensing for the control of salt-intake behavior. Although Nax was also suggested to b...
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Dehydration causes an increase in the sodium (Na) concentration and osmolarity of body fluids. For Na homeostasis of the body, control of Na and water intake and excretion are of prime importance. Although the circumventricular organs (CVOs) were suggested to be involved in body-fluid homeostasis, the system for sensing Na levels within the brain, which is responsible for the control of Na- and...
متن کاملSodium-level-sensitive sodium channel and salt-intake behavior.
Mammals feel thirsty or develop an appetite for salt when the correct balance between water and sodium in the body fluid has been disrupted, but little is known about the mechanism in the brain that controls salt homeostasis. It has been postulated that the existence of both an osmoreceptor and a specific sodium receptor is required to accommodate the experimental data (Johnson and Edwards, 199...
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The sensory circumventricular organs (CVOs) are specialized collections of neurons and glia that lie in the midline of the third and fourth ventricles of the brain, lack a blood-brain barrier, and function as chemosensors, sampling both the cerebrospinal fluid and plasma. These structures, which include the organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), and area po...
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